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2 edition of Quantitation and mass spectrometric data of drugs and isotopically labeled analogs found in the catalog.

Quantitation and mass spectrometric data of drugs and isotopically labeled analogs

Ray H. Liu

Quantitation and mass spectrometric data of drugs and isotopically labeled analogs

  • 330 Want to read
  • 36 Currently reading

Published by Taylor & Francis in Boca Raton .
Written in English

    Subjects:
  • Drugs -- Analysis,
  • Central nervous system -- Effect of drugs on,
  • Radiolabeling,
  • Mass spectrometry,
  • Pharmaceutical Preparations -- analysis,
  • Central Nervous System Agents -- chemistry,
  • Isotope Labeling,
  • Mass Spectrometry -- methods

  • Edition Notes

    Includes bibliographical references and index.

    StatementRay H. Liu, Sheng-Meng Wang, Dennis V. Canfield.
    ContributionsWang, Sheng-Meng., Canfield, Dennis V., 1943-
    Classifications
    LC ClassificationsRS189.5.S65 L58 2010
    The Physical Object
    Paginationp. ;
    ID Numbers
    Open LibraryOL24061234M
    ISBN 109781420094978
    LC Control Number2009026283


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Quantitation and mass spectrometric data of drugs and isotopically labeled analogs by Ray H. Liu Download PDF EPUB FB2

Assisting scientists with this process, Quantitation and Mass Spectrometric Data of Drugs and Isotopically Labeled Analogs provides an extremely valuable reference for labs involved in the analysis of therapeutic and abused by: 7.

Quantitation and Mass Spectrometric Data of Drugs and Isotopically Labeled Analogs - Kindle edition by Ray H. Liu, Dennis V. Canfield, Sheng-Meng Wang.

Download it once and read it on your Kindle device, PC, phones or tablets. Use features like bookmarks, note taking and highlighting while reading Quantitation and Mass Spectrometric Data of Drugs and Isotopically Labeled Analogs.5/5(1). Quantitation and Mass Spectrometric Data of Drugs and Isotopically Labeled Analogs - CRC Press Book The analysis of drugs and their metabolites in biological media are now expected to routinely achieve ± 20% accuracy in the ng/mL concentration level.

Assisting scientists with this process, Quantitation and Mass Spectrometric Data of Drugs and Isotopically Labeled Analogs provides an extremely valuable reference for labs involved in the analysis of therapeutic and abused drugs. Part One of this comprehensive volume illustrates approaches, mechanisms.

RETURN TO ISSUE PREV Book Review Quantitation and Mass Spectrometric Data of Drugs and Isotopically Labeled Analogs Cite this: J. Chem. Soc., 31, Part II of the book makes up the majority and contains the mass spectra of commonly abused drugs and their isotopically labeled analogs in various derivatized forms.

The EI mass spectra were obtained by GC-MS; they are organized in various figures and located in Author: Michael L. Gross. Aiding scientists with this course of, Quantitation and Mass Spectrometric Data of Drugs and Isotopically Labeled Analogs provides a very helpful reference for labs involved inside the analysis of therapeutic and abused drugs.

• Liu RH, Wang S-M, Canfield DV: Quantitation and Mass Spectrometric Data of Drugs and Isotopically Labeled Analogs; CRC Press: Boca Raton, FL; pp; Invited Book Chapters • Liu RH: Mass Spectrometry of Commonly Abused Drugs; In Yinon J (Ed): Forensic Mass Spectrometry; CRC Press: Boca Raton, FL; Chapter 1;   With the combination of AMP, MDA, and PPA as the analytes, their commercially available isotopically labeled analogs as the internal standards, and the use of TFA, PFP, HFB, and t-BDMS as the first and the second derivatization groups, a total of 77 full-scan mass spectra are systematically by: 5.

Gas chromatography-mass spectrometry (GCMS) is the preferred method for the analysis of drugs/metabolites in biological specimens with use of isotopically labeled analogs of the analytes as internal standards (ISs).

An important aspect of the chemical derivatization (CD). Quantitation of Drug in Biological Specimen {u} Isotopically Labeled Analog of the Analyte as Internal Standard --Isotopically Labeled Analog of the Analyte as Internal Standard for Drug Quantitation {u} Chemical Derivatization and Data Collection and Evaluation --Mass Spectra of Commonly Abused Drugs and their Isotopically Labeled Analogs in Various Derivatization Forms --Cross-contributions of Ion Intensity Between Analytes and their Isotopically Labeled Analogs.

At present, the use of stable isotopic nuclei (13 C, 15 N, 2 H) in concert with mass spectrometry (MS) for quantitative analyses is commonplace in the small-molecule amounts of isotopically labeled versions of drugs or metabolites are spiked into a sample and compared with the unlabeled variant, in what is widely regarded as the best way to apply an internal standard for the Cited by:   Isotopically labeled analogs of the analytes are often used as the ISs (in a quantitation protocol) to eliminate or minimize the impact of matrix effects.

With nearly the same physicochemical properties exhibited by the analytes, isotopically labeled ISs can compensate for matrix effects affecting the analytes in the sample pretreatment Cited by: Isotopically Labeled Analog as Internal Standard for Drug Quantitation: Methodology -- Chapter 1 Quantitation of Drug in Biological Specimen: Isotopically Labeled Analog of the Analyte as Internal Standard -- Introduction -- Significance of Accurate Quantitation -- Preferred Calibration Method -->Internal Standard and Quantitation Ions -- Inadequate Isotopic Purity: An Extrinsic Factor -- Cross.

Quantitation and Mass Spectrometric Data of Drugs and Isotopically Labeled Analogs Ray H. Liu Sheng-Meng Wang Dennis V. Canfield With the assistance of. Quantitation and mass spectrometric data of drugs and isotopically labeled analogs by Ray H.

Liu 1 edition - first published in 1. Author(s): Liu,Ray H; Wang,Sheng-Meng; Canfield,Dennis V, Title(s): Quantitation and mass spectrometric data of drugs and isotopically labeled analogs/ Ray H.

Liu, Sheng-Meng Wang, Dennis V. Canfield ; with the assistance of Meng-Yan Wu. McKenzie et al. reported a dynamic Solid Phase Microextraction (SPME) sampling method combined with gas chromatography-mass spectrometry. Quantitation of fentanyl analogs in dried blood spots by flow-through desorption coupled to online solid phase extraction tandem mass spectrometry† Rebecca L.

Shaner, a Nicholas D. Schulze, b Craig Seymour, b Elizabeth I. Hamelin, * a Jerry D. Thomas a and Rudolph C. Johnson a. An isotopically labeled internal standard will have a similar extraction recovery, ionization response in ESI mass spectrometry, and a similar chromatographic retention time.

If you are performing non- clinical PK quantitation it may be difficult to justify such a standard since a special synthesis of an isotopically labeled standard can be. The aim of this dissertation was the development of mass spectrometric assays for the quantitation of therapeutic drugs and drugs of abuse in body fluids.

New purification and separation techniques were used and their benefit on the performance of the assay was shown in comparison to established sample preparation and separation methods. Isotopic labeling (or isotopic labelling) is a technique used to track the passage of an isotope (an atom with a detectable variation in neutron count) through a reaction, metabolic pathway, or cell.

The reactant is 'labeled' by replacing specific atoms by their isotope. The reactant is. Opioids Using a Triple-Quadrupole GC/MS/MS Pittcon P Laura Chambers, Richard Whitney, Ph.D., Nicole M. using isotopically-labeled analogs of target compounds as internal standards, is a widely used analytical approach for precise quantitation in drug assays.

However, in File Size: 1MB. isotopically-labeled analogs of target compounds as internal standards, is a widely used analytical approach for precise quantitation in drug assays. However, in many cases, when using deuterium-labeled analogs the mass spectra differ only slightly from the File Size: KB.

Zeland Muccio and Glen P. Jackson; Isotope ratio mass spectrometry. First published as an Advance Article on the web 14th November DOI: /bd. Ray H. Liu, Dennis V. Canfield, Sheng-Meng Wang; Quantitation and Mass Spectrometric Data of Drugs and Isotopically Labeled Analogs.

Published: August 5, by CRC Press. between the Analytes and Their Isotopically Labeled Analogs REFERENCE: Wang S-M, Chye S-M, Liu RH, Lewis RJ, Canfield DV, Roberts J: Mass spectrometric data of commonly abused amphetamines and their derivatives — Cross contributions of ion intensity between the analytes and their isotopically labeled analogs; Forensic Sci Rev –; Rapid Communications in Mass Spectrometry,vol – Hintikka L, Kuuranne T, Leinonen A, Thevis M, Schanzer W, Halket J, Cowan D, Grosse J, Hemmersbach P, Nielen MWF and Kostiainen R.

Liquid chromatographic–mass spectrometric analysis of glucuronide-conjugated anabolic steroid metabolites: method validation and. as heavy labeled analogs (i.e. having exactly the same chemical properties, including ionization potential, as the identified marker peptides).

Known amounts of these isotopically labeled peptides are then spiked into samples of interest. Triple Quadrupole mass spectrometry is then used toFile Size: KB.

Quantitation by GC–MS of Methylglyoxal as a Marker in Anxiety-Related Studies Quantitation by GC–MS of Methylglyoxal as a Marker in Anxiety-Related Studies Chen, Bud-Gen; Lin, Chia; Chen, Chinpiao; Hambsch, Boris; Chern, Chi-Liang Methylglyoxal (MG) is present in the human system.

In the cell, MG is degraded by glyoxalase 1 (Glo 1), an enzyme. Broad portfolio—extensive offering of both kits and individual reagents for discovery and targeted Mass Spec Protein Quantitation Compatible —optimized for use with Thermo Scientific LC-MS or LC-MS/MS platforms with data analysis fully supported by Proteome Discoverer or Pinpoint   Liquid chromatography-tandem mass spectrometric assay for the quantitation in human plasma of the novel indenoisoquinoline topoisomerase I inhibitors, NSC and NSC Julianne L.

Holleran, a Robert A. Parise, a Archibong E. Yellow-Duke, a Merrill J. Egorin, a, b, c Julie L. Eiseman, a, c Joseph M. Covey, d and Jan H. Beumer a, eCited by: 9. Liu RH, Wang S-M, Canfield DV: Quantitation and Mass Spectrometric Data of Drugs and Isotopically Labeled Analogs; CRC Press: Boca Raton, FL; ).

[] Lochmuller CH, Souter RW: Chromatographic resolution of enantiomers; J Chromatogr ; Mass spectral results in full scan (Q3 scan) mode.

The full scan mass spectra of hydrocodone-d 3 and hydrocodone are shown in Figure 3a and e features of these mass spectra are the prominent molecular ions for the labeled and unlabeled compounds at m/z andrespectively, with the difference of 3 m/z units associated with the isotopically labeled n-methyl group on hydrocodone-d 3.

Quantitative proteomics is mainly performed by two-dimensional gel electrophoresis (2-DE) or mass spectrometry (MS). However, a recent developed method of quantitative dot blot (QDB) analysis is able to measure both the absolute and relative quantity of an individual.

Mass spectrometric determination of insulins and their degradation products in sports drug testing Determination of human insulin and its analogues in human blood using liquid chromatography coupled to ion mobility mass spectrometry (LC-IM-MS), Drug Testing and Advances in the quantitation of therapeutic insulin analogues by LC–MS/MS.

The present invention makes use of unique tags of a specific biopolymer that can be exploited for determining the concentration the biopolymer in crude solutions.

In preferred embodiments the biopolymer is either a protein or a polynucleotide. Particularly, the invention provides a method for the determination and quantitation of biomolecules in crude mixtures by way of a separatioln technique Cited by: The difference between the molecular masses of the analyte and isotopically labeled internal standard should be at least three mass units to avoid overlapping in monitored mass peaks.

The use of an internal standard corrects variations in mass spectrometric response and in extraction recovery and minimizes possible matrix by: Quantitation and Mass Spectrometric Data of Drugs and Isotopically Labled Analoges CRC Press: New York January 1, The Distribution of Tramadol in Postmortem Human Fluids and TissuesTitle: Toxicologist/Chemist at Federal.

drug treatment. Heavy Isotope-labeled Peptides in Mass Spectrometry Biological molecules such as proteins mainly consist of carbon, hydrogen, nitro-gen, and oxygen. None of these elements is monoisotopic, they exist as stable and radioactive isotopes, i.e.

atoms with dif-fering atomic weight. 13C has the same number of protons and electrons as File Size: KB. Measurement of intact proteins by mass spectrometry can be problematic. In order to make proteins more amenable to mass spectrometric detection, the proteins are commonly digested with a proteolytic enzyme prior to analysis.

Quantitation can then be performed by adding known amounts of isotopically labeled peptides as internal standards. Mirgorodskaya, O.A. et al. Quantitation of peptides and proteins by matrix-assisted laser desorption/ionization mass spectrometry using (18)O-labeled internal standards.

Rapid Commun. Mass Cited by: Analogs — Benzodiazepines and Their Derivatives REFERENCE: Wang S-M, Chen B-G, Wu M-Y, Liu RH, Lewis RJ, Ritter RO, Canfield DV: Mass spectra and cross-contributions of ion intensity between drug analytes and their isotopically labeled analogs — Benzodiazepines.Scientific (Hampton, New Hampshire).

Most drugs and stable isotopically labeled analogs were purchased from Cerilliant (Reston, VA, USA) as 1 mg/mL or µg/mL stock solutions and stored at −20 °C.

Exceptions were sulfamethazine (Sigma, St Louis, MO, USA), 2[H]4-sulfamethazine and 2[H]7-atenolol (CDN Isotopes, Pointe-Claire, Quebec, Canada.